Design and Characterization of Power Converters and Amplifiers for Supply-Modulation based Transmitter Architectures

The rapid evolution of telecommunication systems has strongly influenced our lives, and the way we communicate and exchange information. Nevertheless, much progress is expected to happen in the next years with the introduction of new generations of wireless communications standards, which require signals with large bandwidth and very high Peak-to-Average Power Ratio (PAPR) in order to enhance the spectral efficiency and maximize the data rate. However, such developments can only take place through the evolution of Radio-Frequency (RF) which should be capable of working at higher frequencies, higher bandwidth and with higher efficiencies than before. In order to meet these demanding specifications, transmitter architectures have to evolve from a single linear RF Power-Amplifier (PA) into more complex architectures. Envelope Tracking (ET) is one of the most promising solutions for the efficiency-enhancement of next generation transmitters. The research described in this thesis aims to provide solutions to enhance the efficiency of the RF PA by means of an ET architecture. To this purpose, a novel discrete level supply modulator is investigated, which is based on a direct digital-to-analog power conversion. This supply modulator is capable of synthesizing eight voltage steps by means of three isolated voltage sources, thus behaving like a Power Digital-to-Analog Converter (Power-DAC). A hybrid version of the Power-DAC exploiting very fast GaN devices is developed and tested with an L-band PA achieving efficiency improvement up to 13% with 10 MHz of bandwidth. Furthermore, a monolithic GaN version of the Power-DAC is prototyped and tested with an X-band PA achieving efficiency improvement up to 20% and bandwidth of 20 MHz. This supply modulator is tested with outphasing PAs showing promising results with modulated signals and efficiency improvement up to 9%. Finally, dispersive phenomena, which affect PAs and switches in supply modulators, are investigated, characterized and modeled

The VEI 2 Christmas 2018 Etna Eruption: A Small But Intense Eruptive Event or the Starting Phase of a Larger One?

The Etna flank eruption that started on 24 December 2018 lasted a few days and involved the opening of an eruptive fissure, accompanied by a seismic swarm and shallow earthquakes, significant SO2 flux release, and by large and widespread ground deformation, especially on the eastern flank of the volcano. Lava fountains and ash plumes from the uppermost eruptive fissure accompanied the opening stage, causing disruption to Catania International Airport, and were followed by a quiet lava effusion within the barren Valle del Bove depression until 27 December. This was the first flank eruption to occur at Etna in the last decade, during which eruptive activity was confined to the summit craters and resulted in lava fountains and lava flow output from the crater rims. In this paper, we used ground and satellite remote sensing techniques to describe the sequence of events, quantify the erupted volumes of lava, gas, and tephra, and assess volcanic hazards.Publishedid 9056V. Pericolosità vulcanica e contributi alla stima del rischioJCR Journa

The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase

BACKGROUND: The involvement of Heat Shock Proteins (HSP) in cancer development and progression is a widely debated topic. The objective of the present study was to evaluate the presence and expression of HSP60 and HSP10 in a series of large bowel carcinomas and locoregional lymph nodes with and without metastases. METHODS: 82 Astler and Coller's stage C2 colorectal cancers, of which 48 well-differentiated and 34 poorly-differentiated, were selected along with 661 lymph nodes, including 372 with metastases and 289 with reactive hyperplasia only, from the same tumours. Primitive tumours and both metastatic and reactive lymph nodes were studied; specifically, three different compartments of the lymph nodes, secondary follicle, paracortex and medullary sinus, were also analysed. An immunohistochemical research for HSP60 and HSP10 was performed and the semiquantitative results were analysed by statistical analysis to determine the correlation between HSPs expression and 1) tumour grading; 2) degree of inflammation; 3) number of lymph nodes involved; 4) lymph node compartment hyperplasia. Moreover, western blotting was performed on a smaller group of samples to confirm the immunohistochemical results. RESULTS: Our data show that the expression of HSP60, in both primary tumour and lymph node metastasis, is correlated with the tumoral grade, while the HSP10 expression is not. Nevertheless, the levels of HSP10 are commonly higher than the levels of HSP60. In addition, statistical analyses do not show any correlation between the degree of inflammation and the immunopositivity for both HSP60 and HSP10. Moreover, we find a significant correlation between the presence of lymph node metastases and the positivity for both HSP60 and HSP10. In particular, metastatic lymph nodes show a higher percentage of cells positive for both HSP60 and HSP10 in the secondary follicles, and for HSP10 in the medullary sinuses, when compared with hyperplastic lymph nodes. CONCLUSION: HSP60 and HSP10 may have diagnostic and prognostic significance in the management of this tumour and their overexpression in tumoral cells may be functionally related to tumoral progression. We hypothesise that their expression in follicular and medullary cells of lymph nodes may be induced by formation of metastases. Further studies based on these observations could lead to a better understanding of the HSPs involvement in colorectal cancer progression, as well as other neoplasms